Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 89, Pages 13729-13731Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc05657d
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Funding
- Health Research Council of New Zealand [11/323]
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The (OH)-O-center dot radical is released from 3-trifluoromethyl-quinoxaline 1,4-dioxides upon one-electron reduction by cytochrome P450 oxidoreductase. This process effectively competes with back oxidation of the intermediate radical anion by oxygen and underlies the increased aerobic cytotoxicity of such compounds compared to that seen for the related clinical bioreductive benzotriazine drug, tirapazamine.
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