Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 44, Pages 5887-5890Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc01994f
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Funding
- Universite d'Orleans
- INSA de Rouen
- Universite de Rouen
- CNRS
- LABEX SynOrg [ANR-11-LABX-0029]
- MESR
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Copper-catalyzed olefinic difluoroacetylation of enamides via direct C-H bond functionalization using BrCF2CO2Et is reported for the first time. It constitutes an efficient radical-free method for the regioselective synthesis of beta-difluoroester substituted enamides which exhibits broad substrate scope, and thus demonstrates its potent application in a late stage fluorination strategy.
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