Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 80, Pages 11810-11813Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc02996h
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Funding
- BRNS [2010/35/19/BRNS]
- Deakin University [211640938]
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For the first time, a novel EpCAM aptamer (SYL3C)-DIBO-AF594 fluorescent conjugate was synthesised by bioorthogonal chemistry utilizing a strain promoted alkyne-azide cycloaddition (copper free click) reaction (SPAAC). The ligation efficiency of SPAAC was improved by freeze-thaw cycles. The obtained conjugate showed target specific binding and aided in the imaging of various EpCAM positive cancer cell lines like MCF7, MDAMB453, Weri-RB1 and PC3.
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