4.7 Article

Rhodium-catalyzed direct synthesis of unprotected NH-sulfoximines from sulfoxides

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 68, Pages 9687-9689

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc04349a

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Funding

  1. Indiana University Purdue University Indianapolis
  2. NSF-MRI award [CHE-0619254]

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A novel rhodium-catalyzed imination of sulfoxides using O-(2,4-dinitrophenyl)hydroxylamine is developed under mild conditions with good functional group tolerance. This method provides an efficient access to free NH-sulfoximines, an important structural unit in a variety of biologically active compounds.

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