4.7 Article

Rational design of sulfoxide-phosphine ligands for Pd-catalyzed enantioselective allylic alkylation reactions

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 22, Pages 2873-2875

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc49488h

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Funding

  1. National Science Foundation of China [21272087, 21002036, 21202053]
  2. National Basic Research Program of China [2011CB808603]
  3. Central China Normal University [CCNU13T04060, 2013YBYB54]

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A new type of chiral sulfoxide-phosphine ligands have been developed by a rational combination of two privileged scaffolds for Pd-catalyzed asymmetric allylic alkylation reactions. Under optimized conditions, generally high yields (up to 97%) and excellent enantioselectivities (up to >99% ee) were obtained.

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