Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 77, Pages 11415-11417Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc05058d
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Funding
- Generalitat de Catalunya [2009/SGR/ 00279]
- Spanish Ministry of Economy and Competitiveness [CTQ2010-16237]
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A labelling method for the covalent attachment of radioiodine to the boron-rich 8-I-cobaltabisdicarbollide (I-COSAN) and a bi-functional (iodine and PEG) COSAN derivative, [3,3'-Co(8-I-1,2-C2B9H10)(8'-(OCH2CH2)(2)COOC6H5-1',2'-C2B9H10)], is reported. Biodistribution studies in rodents using dissection/gamma counting and in vivo nuclear imaging have been performed. The general strategy reported here can be applied in the future to COSAN derivatives bearing a wide range of functionalities.
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