4.7 Article

Reversible Ag+-crosslinked DNA hydrogels

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 31, Pages 4065-4068

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc49140d

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Funding

  1. MICREAgents project of the EC Seventh Framework Programme and the Volkswagen Foundation, Germany [318671]

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DNA hydrogels, consisting of Y-shaped nucleic acid subunits or of nucleic acid-functionalized acrylamide chains, undergo switchable gel-to-solution transitions. The Ag+-stimulated formation of cytosine Ag+-cytosine complexes results in the crosslinking of the units to yield the hydrogels, while the cysteamine-induced elimination of the Ag+ ions dissociates the hydrogels into a solution phase.

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