Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 82, Pages 12329-12332Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc03888f
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2012R1A1A3015259]
- Center for BioNano Health-Guard - MSIP of Korea as Global Frontier Project [H-GUARD_2013M3A6B2078964]
- ARO Institute for Collaborative Biotechnologies [W911F-09-D-0001]
- National Institutes of Health [U54 DK093467, U01HL099773-01, R01A1076899]
- Department of Defense [W81XWH-09-0698]
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We describe an aptamer-conjugated polydiacetylene imaging probe (ACP) that shows highly specific fluorescence switching upon binding to epithelial cancer cells that overexpress the tumor biomarker protein EpCAM (epithelial cell adhesion molecule) on their surface.
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