Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 53, Pages 6991-6994Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc00137k
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Funding
- JSPS [21655060]
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Grants-in-Aid for Scientific Research [26282214, 26560444] Funding Source: KAKEN
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Cylindradines A and B, members of the polycyclic pyrrole-imidazole alkaloids (PIAs), are the only congeners bearing a 3-carbamoylpyrrole unit among the PIAs. In this communication, we described a total synthesis of (+)-cylindradine A based on intramolecular Friedel-Crafts type cyclization of pyrrole-aldehyde and oxidative cyclization of tricyclic pyrrolopyrrolidine-guanidine with hypervalent iodine to construct the cyclic guanidine structure including the N,N'-aminal moiety.
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