4.7 Article

Efficient synthesis of fluorescent-PET probes based on [18F]BODIPY dye

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 55, Pages 7371-7373

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc01411a

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Funding

  1. American Cancer Society [MSRG-12-034-01-CCE]
  2. USC Department of Radiology
  3. Loker Hydrocarbon Research Institute

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We report the direct conversion of fluorescent probes to PET/fluorescent probes after efficient [F-19]/[F-18] exchange at the BODIPY motif. The radiolabeling of a NIR BODIPY dye was also established, which was conjugated with the RGD peptide for PET/fluorescence imaging of integrin expression in vivo.

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