4.7 Article

A highly sensitive nucleic acid stain based on amino-modified tetraphenylethene: the influence of configuration

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 49, Pages 6494-6497

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc02671c

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Funding

  1. National Science Fund for Distinguished Young Scholars of China [51125013]
  2. program for Changjiang Scholars and Innovative Research Team in University [IRT1030]
  3. Research Fund for the Doctoral Program of Higher Education of China [20120141110029]
  4. PhD independent research projects of Wuhan University [2012203020214]

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We designed and synthesized a new amino-functionalized tetraphenylethene (TPE) derivative as a highly sensitive dye for the detection of dsDNA and oligonucleotide in both solution and a gel matrix. We further revealed that the cis configuration dye showed a much higher sensitivity than its trans isomer for the first time.

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