4.7 Article

Phosphorylated dendronized poly(amido amine)s as protein analogues for directing hydroxylapatite biomineralization

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 49, Pages 6491-6493

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc00617h

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Funding

  1. National Natural Science Foundation of China [51322303]
  2. Foundations of Sichuan Province [2012JQ0009]

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Dendronized poly(amido amine) s (DPs) bearing tri-phosphate or bis-phosphonate peripheral groups are synthesized. These worm-like DPs can template the formation of BMSCs adhesive hydroxylapatite (HA) on the nano-scale, or self-assemble into mineral-collecting microfibers on the micro-scale, exhibiting similar functions of non-collagenous proteins (NCPs) in the natural biomineralization process of HA.

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