4.7 Article

Synthesis and properties of a Cu(II) complexing pyrazole ligandoside in DNA

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 4, Pages 409-411

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc47561a

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Funding

  1. Alexander von Humboldt Foundation
  2. Volkswagen Foundation
  3. DFG [SFB749, TP4, SFB1032, TPA5]

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The development of metal base pairs is of immense importance for the construction of DNA nanostructures. Here we report the synthesis of a biaryl pyrazole-phenol nucleoside that forms in DNA a stable self-pair upon complexation of a Cu(II) ion. A sequence with five consecutive pyrazole nucleotides allows the complexation of five Cu(II) ions in a row.

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