Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 68, Pages 9714-9717Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc03385j
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Funding
- National Basic Research Program of China [2011CB935800]
- National Natural Science Foundation of China [21271100, 91213305, 10979019, 21131003, 21021062]
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Synergistic release of platinum anticancer drugs and O-2 can be achieved in an H2O2-responsive nanocarrier incorporated with catalase. Such a system combines the advantages of chemotherapy and oxygen therapy and demonstrated improved therapeutic efficacy against cisplatin resistant cell lines which often appear to be in hypoxia.
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