4.7 Article

A highly sensitive electrochemical genosensor based on Co-porphyrin-labelled DNA

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 32, Pages 4196-4199

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc00172a

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Funding

  1. Innovative Economy Program [WND-POIG.01.01.02-00-007/08]
  2. BBSRC (DTA)

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We report the use of Co-porphyrins as electrochemical tags for a highly sensitive and selective genosensor. An avian influenza virus-based DNA sequence characteristic of H5N1 was detected at femtomolar levels from competing non-complementary sequences through hybridisation with the labeled DNA.

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