Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 56, Pages 7507-7510Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc02301c
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Funding
- National Cancer Center, Republic of Korea [1310160]
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We have developed a folate receptor-specific activatable probe for in vivo near-infrared fluorescence imaging of ovarian cancer. This probe becomes highly fluorescent only when its linker is cleaved by a tumor-associated lysosomal enzyme cathepsin B after internalization into folate receptor-positive cancer cells.
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