Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 8, Pages 960-963Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc48616h
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Funding
- National Institutes of Health NIAID [AI-064200]
- MRC Confidence in Concept grant
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We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent in vitro anti-proliferative activity.
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