4.7 Article

Regio- and stereoselective synthesis of 2-cyclopentenones via a hydrogenolysis-terminated Heck cyclization of beta-alkylthio dienones

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 22, Pages 2201-2203

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc37571d

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Funding

  1. State Key Laboratory of Fine Chemicals [KF1003]
  2. [NNSFC-21172031/20972029]

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Palladium-catalyzed cyclization of beta-alkylthio dienone derivatives affords 2-cyclopentenones in a regio- and stereoselective manner in the presence of silane. C-S activation, intramolecular carbopalladation and hydrogenolysis construct the cascade process.

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