Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 42, Pages 4749-4751Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc41452c
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Funding
- NIH [GM094693]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM094693] Funding Source: NIH RePORTER
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A small molecule, protein mimetic based approach is shown to specifically inhibit lipid catalysed self-assembly of islet amyloid polypeptide (IAPP). The lipid-bound oligomerization of this peptide is implicated in cellular dysfunction of insulin secreting beta-cells in type II diabetes.
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