Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 62, Pages 6974-6976Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc43576h
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Funding
- NSFC [51273188, 81201176]
- FANEDD [201224]
- SRFDP [20123402120022]
- APNSF [1208085QB21]
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A matrix metalloproteinase-cleavable peptide-linked block copolymer was fabricated and utilized to construct PEG-sheddable polyplex micelles as smart gene delivery vectors, which were demonstrated to exhibit higher cellular uptake, improved endosomal escape, and high-efficiency gene transfection in the presence of matrix metalloproteinase-2.
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