4.7 Article

Assistant DNA recycling with nicking endonuclease and molecular beacon for signal amplification using a target-complementary arched structure

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 38, Pages 4006-4008

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc40723c

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Funding

  1. National Basic Research Program of China [2010CB732400]
  2. National Natural Science Foundation of China [21121091, 21135002]

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A simple and universal method for ultrasensitive signal on'' detection of DNA was developed with a target-complementary arched structure to release assistant DNA, which was recycled with nicking endonuclease to amplify the detectable fluorescent signal of molecular beacons.

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