Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 95, Pages 11133-11148Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc46266h
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Funding
- National Science Foundation [CHE-0847262]
- University of Connecticut
- Division Of Chemistry [0847262] Funding Source: National Science Foundation
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Trifluoromethyl ketones (TFMKs) are exceedingly valuable synthetic targets in their own right and as synthons in the construction of fluorinated pharmacons. This Feature Article provides an overview of the properties of TFMKs, an in-depth discussion of the methods available for their synthesis, and two illustrative examples of their application as key intermediates in medicinal chemistry.
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