Na+/K+ switch of enantioselectivity in G-quadruplex DNA-based catalysis

Here we found that the enantioselectivity of G-quadruplex DNA-based Diels-Alder reaction can be switched by just changing Na+ to K+, which is ascribed to the structural transformation of the G-quadruplex from antiparallel to hybrid-type. By tuning the ratio of Na+/K+, the enantioselectivity of the Diels-Alder reaction could be switchable and shows much more sensitive to K+ than to Na+.