Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 42, Pages 4791-4793Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc40869h
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Funding
- Australian National Health and Medical Research Council (NHMRC) [568841]
- University of Wollongong
- University of New South Wales
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Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3 '-diazeniumdiolates as biofilm-targeted NO-donor prodrugs. Each of the compounds is shown to selectively release NO following reaction with the bacteria-specific enzyme beta-lactamase and to trigger dispersion of Pseudomonas aeruginosa biofilms in vitro.
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