4.7 Article

Perfecting WATERGATE: clean proton NMR spectra from aqueous solution

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 4, Pages 358-360

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc37579f

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Funding

  1. Engineering and Physical Sciences Research Council [EP/H024336/1, EP/I007989/1]
  2. EPSRC [EP/I007989/1, EP/H024336/1] Funding Source: UKRI
  3. Engineering and Physical Sciences Research Council [EP/H024336/1, EP/I007989/1] Funding Source: researchfish

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A simple modification of the WATERGATE solvent suppression method greatly improves the quality of H-1 NMR spectra obtainable from samples in H2O. The new method allows H-1 signals to be measured even when close in chemical shift to the signal of water, as for example in the NMR spectra of carbohydrates.

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