4.7 Article

Synthesis of (spiro)cyclopentapyridinones via C-sp3-H functionalization: a post-Ugi gold-catalyzed regioselective tandem cyclization

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 64, Pages 7171-7173

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc43418d

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Funding

  1. University of Leuven (KU Leuven)
  2. FWO (Fund for Scientific Research-Flanders (Belgium)
  3. Hercules Foundation [AKUL/09/0035]
  4. EMEC, lot 13 (Erasmus Mundus External Cooperation Window Lot 13)

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A gold-catalyzed regioselective tandem cyclization of N-propynyl-butynamide via C-sp3-H functionalization has been described, providing a distinctive methodology for the architecture of cyclopentapyridinones as well as spirocyclopentapyridinones.

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