4.7 Article

Transition-metal-free oxidative trifluoromethylation of unsymmetrical biaryls with trifluoromethanesulfinate

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 48, Pages 5510-5512

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc41667d

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Funding

  1. Platform for Drug Discovery, Informatics, and Structural Life Science from the Ministry of Education, Culture, Sports, Science and Technology, Japan
  2. Asahi Glass Foundation

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A transition-metal-free direct oxidative trifluoromethylation of unsymmetrical biaryls has been achieved by the simple combination of trifluoromethanesulfinate and phenyliodine bis(trifluoroacetate). The trifluoromethylation is selectively observed in the electron-rich arenes.

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