4.7 Article

A new turn-on fluorescent probe for selective detection of glutathione and cysteine in living cells

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 41, Pages 4640-4642

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc39045d

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Funding

  1. National Natural Science Foundation of China [21275051, 20975037, 21005037]
  2. Scientific Research Fund of Hunan Provincial Education Department [12A084]
  3. Aid program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province

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A fluorescent probe (N-(4-methyl-2-oxo-2H-chromen-7-yl)-2,4-dinitrobenzenesulfonamide), which exhibits high selectivity to glutathione and cysteine among amino acids including sulphur-containing methionine and metal ions, was synthesized. The experiments demonstrate that the fluorescent probe is a reliable and specific probe for glutathione and cysteine in living cells.

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