Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 49, Pages 5535-5537Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc40758f
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- Eisai Research Foundation
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N-(2-Chlorobenzyl)-substituted hydroxamate, readily produced by hydrolysis of ketoclomazone, was identified as an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase (DXS), with an IC50 value of 1.0 mu M. The compound inhibited the growth of Haemophilus influenzae. A convenient spectroscopic method for assaying DXS using NADPH-lactate dehydrogenase (LDH) is also reported.
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