Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 36, Pages 3805-3807Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc41027g
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Funding
- Intra European Fellowship [MC-IEF-275329]
- Faculty of Health and Medical Sciences at the University of Copenhagen
- Lundbeck Foundation
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Tetrazine-trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first C-11-labelled tetrazine and its reaction with trans-cyclooctenol.
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