Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 69, Pages 7620-7622Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc43725f
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- Ministry of Education, Culture, Sports, Science and Technology, Japan [24790121]
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Based on a novel concept, a Reducing-Environment-Dependent Uncatalyzed Chemical Transforming RNA, REDUCT RNA, we established a post-synthetic approach for the synthesis of 2'-O-methyldithiomethyl-modified oligonucleotides from 2'-O-(2,4,6-trimethoxybenzylthiomethyl)-oligonucleotides by treatment with dimethyl(methylthio)sulfonium tetrafluoroborate. 2'-O-methyldithiomethyl oligonucleotides were easily converted into 2'-hydroxy oligonucleotides under reducing conditions, such as those found in the intracellular environment.
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