Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 43, Pages 4968-4970Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc41896k
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Funding
- National Science Foundation [DMR 1255281]
- Johns Hopkins University (JHU)
- NIH [T-32CA130840, R25CA153952]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1255281] Funding Source: National Science Foundation
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We report here the self-assembly of a rationally designed paclitaxel drug amphiphile into well-defined supramolecular filaments that possess a fixed 41% paclitaxel loading. These filaments can exert effective cytotoxicity against a number of cell lines comparable to that of free paclitaxel.
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