Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 37, Pages 3836-3838Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc00127j
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Funding
- UQ Fellowship Scheme [2009001762]
- Australian Research Council [FT110100284]
- Australian Research Council [FT110100284] Funding Source: Australian Research Council
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Hyperbranched polymers conjugated to a peptide-aptamer were prepared using a combination of RAFT polymerisation and click chemistry for targeting tumour cells in vivo. The polymers showed enhanced cell-uptake in vitro (compared to unconjugated polymer) while excellent specificity for solid tumours was observed in vivo using a mouse model of melanoma.
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