4.7 Article

Curcumin as an amyloid- indicator dye in E. Coli

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 39, Pages 4193-4195

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc37792f

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Funding

  1. NIH [DP2 OD007488]
  2. Stanford Terman Fellowship
  3. Stanford University
  4. Burroughs Wellcome Career Award at the Scientific Interface
  5. Stanford Interdisciplinary Graduate Fellowship

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We have demonstrated that curcumin is an amyloid-specific dye in E. coli. Curcumin binds to curliated whole cells and to isolated curli amyloid fibers. Similar to Congo red, curcumin exhibits a red-shift in absorbance and a significant increase in fluorescence upon binding to isolated curli.

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