Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 74, Pages 8241-8243Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc43368d
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Funding
- Basic Science Research Program [2011-0017356, 2011-0020322, 2011-0016385, 2010-0029167, 2009-0092818]
- Research Center Program of IBS (Institute for Basic Science) through the National Research Foundation of Korea (NRF) [EM1202]
- Korean government (MEST)
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The multifunctional DNAzyme (Dz) delivery system is developed based on nano-sized graphene oxide (nGO) for simultaneous detection and knockdown of the target gene. The Dz/nGO complex system allowed convenient monitoring of HCV mRNA in living cells and silencing of the HCV gene expression by Dz-mediated catalytic cleavage concurrently.
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