4.7 Article

Aminocatalyzed asymmetric Diels-Alder reaction of 2,4-dienals and rhodanine/hydantoin derivatives

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 21, Pages 2157-2159

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc00023k

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Funding

  1. National Natural Science Foundation of China [20902018, 21272068]
  2. Shanghai Municipal Education Commission [11ZZ56]
  3. Fundamental Research Funds for the Central Universities
  4. 111 project [B07023]

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Aminocatalyzed asymmetric Diels-Alder reaction between 2,4-dienals and rhodanine/hydantoin derivatives via trienamine mechanism has been developed to synthesize various spirocyclic compounds with good yields (up to 98%) and excellent stereoselectivities (up to 99% ee and >19 : 1 dr).

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