4.7 Article

A luminescent G-quadruplex switch-on probe for the highly selective and tunable detection of cysteine and glutathione

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 8, Pages 771-773

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc37710a

Keywords

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Funding

  1. Hong Kong Baptist University [FRG2/11-12/009]
  2. Environment and Conservation Fund (ECF) [3/2010]
  3. Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU)
  4. Health and Medical Research Fund [HMRF/11101212]
  5. Research Grants Council [HKBU/201811, HKBU/204612]
  6. Science and Technology Development Fund, Macao SAR [001/2012/A]
  7. University of Macau [SRG013-ICMS12-LCH, MYRG091(Y1-L2)-ICMS12-LCH, MYRG121(Y1-L2)-ICMS12-LCH]

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A G-quadruplex-selective luminescent iridium(III) switch-on probe has been developed for the detection of cysteine (Cys) in aqueous solution. The system is highly sensitive and selective towards Cys with a tunable range of detection. The detection of glutathione (GSH) is also examined.

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