Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 26, Pages 2700-2702Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc40546j
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Funding
- National Science Foundation of China [20932003, 21125209]
- MOST of China [2011CB808600]
- STCSM [12JC1403800]
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An enantioselective four-component reaction of a diazoketone, water, an aniline and ethyl glyoxylate in the presence of catalytic Rh-2(OAc)(4) and a chiral Bronsted acid was developed to efficiently produce beta-hydroxy-alpha-amino acid derivatives in good yields with high diastereoselectivity and enantioselectivity.
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