Palladium-catalyzed cross-coupling of cyclopropanol-derived ketone homoenolates with aryl bromides

The cross-coupling reaction of cyclopropanol-derived ketone homoenolates bearing beta-hydrogens with aryl and hetaryl bromides has been achieved for the first time. This reaction is high yielding, is broad in scope and uses a simple catalytic system. Notably, the proposed palladium homoenolates do not undergo beta-hydride elimination to the corresponding alpha,beta-unsaturated ketones.