Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 87, Pages 10284-10286Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc46361c
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- Swiss National Science Foundation (SNSF)
- Swiss National Centres of Competence in Research (NCCR)
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Reaction of 2-(trimethylsilyl)aryl triflates 1 with N-aryl-alpha-aminoketones 2 afforded N-aryl-2,3-disubstituted indoles in good to excellent yields with complete control of the substitution patterns. This methodology allowed for the first time a one-step synthesis of unsymmetrical 2,3-dialkyl substituted indoles in a regiospecific manner.
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