4.7 Article

Gd3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 6, Pages 564-566

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc37460a

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Funding

  1. BBSRC
  2. GE Healthcare
  3. Medical Research Council [MC_PC_12015] Funding Source: researchfish
  4. MRC [MC_PC_12015] Funding Source: UKRI

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Formyl Peptide Receptors (FPRs) are vital in the host inflammatory response, playing an important regulatory role in multiple diseases. A Gd(III) DOTA conjugate of cFLFLFK has been synthesised which targets and visualises FPR1 upon leukocytes in the inflammatory response via magnetic resonance imaging for the first time.

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