4.7 Article

Design of oligothiophene-based tetrazoles for laser-triggered photoclick chemistry in living cells

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 85, Pages 9920-9922

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc45752d

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Funding

  1. National Institutes of Health [GM 085092]
  2. National Science Foundation [DBI-0923133]
  3. China Scholarship Council

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A 405 nm light-activatable terthiophene-based tetrazole was designed that reacts with a fumarate dipolarophile with the second-order rate constant k(2) exceeding 10(3) M-1 s(-1). The utility of this laser-activatable tetrazole in imaging microtubules in a spatiotemporally controlled manner in live cells was demonstrated.

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