4.7 Article

Biomolecular release triggered by glucose input - bioelectronic coupling of sensing and actuating systems

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 42, Pages 4755-4757

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc42027b

Keywords

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Funding

  1. NSF [CCF-1015983, CBET-1066397]
  2. Division of Computing and Communication Foundations
  3. Direct For Computer & Info Scie & Enginr [1015983] Funding Source: National Science Foundation
  4. Div Of Chem, Bioeng, Env, & Transp Sys
  5. Directorate For Engineering [1066397] Funding Source: National Science Foundation

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A drug-mimicking release process was triggered by a glucose signal resulting in the formation of a negative potential on an electrode modified with PQQ-dependent glucose dehydrogenase. This electrode was coupled with another electrode coated with an Fe+3-crosslinked alginate polymer film, which was dissolved upon formation of the negative potential releasing entrapped species.

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