Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 50, Pages 5621-5629Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc42236d
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Funding
- NCRR NIH HHS [S10 RR023385] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [S10RR023385] Funding Source: NIH RePORTER
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Carbon-11 labelled carbon dioxide is the cyclotron-generated feedstock reagent for most positron emission tomography (PET) tracers using this radionuclide. Most carbon-11 labels, however, are installed using derivative reagents generated from [C-11]CO2. In recent years, [C-11]CO2 has seen a revival in applications for the direct incorporation of carbon-11 into functional groups such as ureas, carbamates, oxazolidinones, carboxylic acids, esters, and amides. This review summarizes classical [C-11]CO2 fixation strategies using organometallic reagents and then focuses on newly developed methods that employ strong organic bases to reversibly capture [C-11]CO2 into solution, thereby enabling highly functionalized labelled compounds to be prepared. Labelled compounds and radiopharmaceuticals that have been translated to the clinic are highlighted.
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