4.7 Article

Clickable LNA/DNA probes for fluorescence sensing of nucleic acids and autoimmune antibodies

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 91, Pages 10751-10753

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc45507f

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Funding

  1. Sapere Aude programme of The Danish Council for Independent Research
  2. VILLUM FOUNDATION
  3. European Research Council under the European Union [268776]
  4. Villum Fonden [00007206] Funding Source: researchfish

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Herein we describe fluorescent oligonucleotides prepared by click chemistry between novel alkyne-modified locked nucleic acid (LNA) strands and a series of fluorescent azides for homogeneous (all-in-solution) detection of nucleic acids and autoimmune antibodies.

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