4.7 Article

A near-infrared dye based on BODIPY for tracking morphology changes in mitochondria

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 90, Pages 10620-10622

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc46143b

Keywords

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Funding

  1. NSF of China [21136002, 20923006, 21076032]
  2. National Basic Research Program of China [2009CB724706, 2013CB733702]
  3. National High Technology Research and Development Program of China (863 Program) [2011AA02A105]
  4. Ministry of Education [NCET-12-0080]

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M-DPT, a BODIPY-based water soluble near-infrared fluorescent probe with thiophene at the 1,7-position, is synthesized. M-DPT is found to possess high specificity to mitochondria, superior photostability, and appreciable tolerance to microenvironmental changes. Thus, this probe is a highly suitable imaging agent for targeting mitochondria and tracking morphology changes.

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