4.7 Article

Metal-free, highly efficient organocatalytic amination of benzylic C-H bonds

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 35, Pages 3700-3702

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc41558a

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Funding

  1. National Natural Science Foundation of China [21172106, 21074054]
  2. National Basic Research Program of China [2010CB923303]
  3. Research Fund for the Doctoral Program of Higher Education of China [20120091110010]
  4. MOE

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A new synthetic approach toward direct C-N bond formation through sp(3) C-H activation has been developed under metal-free conditions. Both primary and secondary benzylic C-H substrates could react smoothly with various amines to give only mono-amination products with good to excellent yields.

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