4.7 Article

A dual-emission and large Stokes shift fluorescence probe for real-time discrimination of ROS/RNS and imaging in live cells

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 18, Pages 1862-1864

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc38471c

Keywords

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Funding

  1. State Key Program of National Natural Science of China [21236002]
  2. National Basic Research Program of China [2010CB126100]
  3. National High Technology Research and Development Program of China [2011AA10A207]
  4. Fundamental Research Funds for the Central Universities

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A novel dual-emission fluorescence probe has been developed for specific and sensitive detection of hypochlorite (ClO-). Upon addition of ClO-, significant changes in fluorescence emission intensity at two discrete wavelengths were observed. Meanwhile OONO- led to only a single-channel fluorescence enhancement. This feature makes it a clear advantage in distinguishing ClO-, RNS from other ROS.

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