Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 31, Pages 3254-3256Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc40577j
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Funding
- National Science Foundation [NSF 21072080, 21272101]
- National Basic Research Program of China (973 Program) [2010CB833203]
- 111'' program of MOE
- PCSIRT [IRT1138]
- Natural Science Foundation of Gansu, PRC [096RJZA006]
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Isoindolines are synthesized by palladium-catalyzed coupling reaction of N-(2-iodobenzyl) anilines with alpha,beta-unsaturated N-tosylhydrazones. The reaction has several potential advantages: (1) toleration of a wide range of functional groups, (2) easy to handle and with mild conditions, (3) enriches the isoindoline family, (4) two new bonds form in one step.
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