Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 90, Pages 10605-10607Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc45459b
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Funding
- Italian Flagship Project NanoMax
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We developed a polymerase reaction free, low-cost and sensitive assay for the colorimetric detection of Human Papilloma Virus (HPV), based on the use of a smart design exploiting magnetic microbeads, chimeric RNA/DNAzyme oligonucleotides, and double signal amplification. This method allows obtaining a fast response with a detection limit of 10 pM, avoiding the amplification of the target via traditional PCR.
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